You Smeared What on Your Smartphone?

Hyun Gyu Park and Byoung Yeon Won at the Korea Advanced Institute for Science and Technology in Daejeon, South Korea believe that a biosample – sputum, saliva, blood, or even urine – could be applied to the screen of a smartphone for analysis. They point out that the screen is capable of detecting extraordinarily small differences in capacitance and it’s that capability which can be leveraged to diagnose everything from influenza to salmonella. The value of the analysis though, hinges on the ability to correlate differences in the capacitance of the sample with something clinically relevant.  While current touchscreens are still not able to identify individual pathogens, the touchscreen’s ability to differentiate between concentrations is a crucial first step.

I’m not sure if I like this idea or not.  Even though I still use the conventional cellular phone, I can see the benefits of using smartphones to communicate and access information quickly.  I just can’t picture myself smearing my bodily excretions on the screen of my phone.  It just seems a bit unsanitary.

 

Drugs In Space

In case you have any plans to go up in space in the near future, be advised…

One of the first publications from the Stability of Pharmacotherapeutic and Nutritional Compounds project determined that after 28 months of storage on the International Space Station some medications degraded faster than controls stored in as similar environment as possible on the ground.

One of the authors, Lakshmi Putcha, Ph.D, said the differences between the ground and control environments “include, but are not limited to, ambient radiation, excessive vibrational forces, multiple gravity environments and carbon dioxide enrichment; this is in addition to unconventional packaging, resupply operations and other unknowns.”

Aside from alerting astronauts to the fact that they may have to plan ahead with their prescriptions, I’m really not sure the practical implications of this study for rest of us earth-bound folk.

 

 

Brown Eyed Girl

Just when I thought I’d heard everything possible in the body-altering department, something new came along.

A Californian company called Stroma Medical has announced that it could use lasers to, in essence, vaporize iris pigment away and thus change eye color. They have been focusing on the brown-eye-to-blue-eye transition by ablating melanin in the stroma (hence the company name).  Like that of the skin, the color of the eye is determined by the presence or absence of pigments such as melanin. Eyes are brown or black when they have melanin in the stroma of the iris; blue or green when they do not.

Call me a purist, but I have never dyed my hair, been “inked”, bleached my teeth, or had any plastic surgery done.  I am fairly happy about the way I look most of the time and prefer to keep my body in its natural state (at least for now) until someone complains about it or I feel inclined otherwise.  My brown eyes are one of my favorite features and I can’t imagine changing them.  Oh well, to each his own…

 

It’s the End of the World as We Know It

Two researchers from University of California, San Francisco and University of Oslo are reporting that inhaled anesthetics significantly contribute to the destruction of the ozone layer and add to the overall global warming gas content in the atmosphere.

As if we don’t have enough to worry about already… Now, as we are already dealing with the stress over any upcoming medical procedures we may have, we have to be concerned that we may be contributing to the end of the world as well.

Go Ahead, Eat All the Chocolate You Want

Chocolate lovers unite!

Cocoa and dark chocolate are rich in flavonoids and may lower blood pressure according to a study performed by the National Heart, Lung, and Blood Institute (NHLBI).  5,000 people aged 25-93 years participated in the Family Heart Study.  Compared to subjects who did not report any chocolate intake, odds ratios for coronary heart disease (CHD) were 0.43 for subjects consuming chocolate 5+ times/week.

I knew my addiction to dark chocolate M&M’s would pay off.  Just don’t let my kids know about this or the jig is up, they’ll be demanding chocolate every chance they get.

 

New Reason for Nerds to Continue to Live in Their Parents’ Basements

I’ve blogged about it before, and evidently I am destined blog about it again, whether I want to or not. There continues to be research that shows the “benefits of video gaming”.  This time, they have somehow managed to find a way to prove the use of video games by adults is helpful.

UCLA Berkley research has suggested that playing video games could improve the vision of adults with amblyopia, or lazy eye.

The study involved a series of experiments in which subjects wore an eye patch over their good eye and played action (shooting at targets) and non-action (constructing objects) video games for a certain period of time over the span of a month. After only 40 hours of play time, the subjects’ visual acuity improved by 30 percent, or an improvement of approximately 1.5 lines on a standard optometric chart. In comparison, it takes an average of 120 hours of conventional occlusion therapy (wearing an eye patch over the good eye to force-train the weaker eye) to yield a 1.0 line improvement.

Who researches this stuff?  I picture guys clad in eyeglasses wearing button down shirts with pocket protectors feverishly playing World of Warcraft while trying to justify multiple hours of game play to their concerned mothers. “Honest Mom, it’s helping my lazy eye.” Must we give my child more ammunition to support his argument that he should be allowed to play video games longer?  I’m happy that medical technology has found a positive use for “those infernal games”; it just makes my job a bit more difficult.

Test for Alzheimer’s

The last year of her life, my mom was in a nursing home with multiple health problems, one of which they believed was Alzheimer’s.  Of course, the doctors could never tell me “She has Alzheimer’s”, because you can’t actually definitively say that someone “has Alzheimer’s” until you do an autopsy of their brain after they are dead.  So, I typically got a dianosis like “She has Alzheimer’s­-like symptoms”. As she died of other health complications before her “Alzheimer’s” progressed too far, I’m still not sure if she actually had Alzheimer’s, or some other form of dementia, although she was on several “Alzheimer’s” drugs.

That may change because scientists at Durin Technologies and the University of Medicine and Dentistry of New Jersey have developed a test that can differentiate between the blood sera of those with AD and those in the non-demented control (NDC) group. The test uses a protein microarray to detect a group of 10 autoantibody biomarkers that the researchers showed could be used as specific and accurate indications of AD: It demonstrated a diagnostic sensitivity (detects positives correctly) of 96% and specificity (detects negatives correctly) of 92.5%.

For the families of those with “Alzheimer’s-like symptoms” I hope this test will eventually make it into clinical use so that they may get the focused medical care for their loved one that is needed.

June 9, 2011 – Integrating & Sustaining Clinical Research

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Indiana Hospital Association andPearl IRB invite you to a webinar:Integrating and Sustaining Clinical Research

June 9, 2011 from 3:00 – 4:30 P.M. EST.

Register Here

 

Featured Presentations

  • Clinical Research: Why Get Involved and How to Do It Right by Gretchen Bowker
  • Sharing Lessons Learned in Building Research Capabilities at One Institution by Robert Plant
  • A Sponsor’s Perspective: What We Look for in a Good Clinical Trial Site by Kara Mezger

During this webinar, you’ll learn:

  • Multiple benefits of clinical research
  • Tactics and operational tips to help start or improve your research program
  • How to plan a practical approach to meet federal regulations as well as identifying characteristics that attract research sponsors to your practice or organization
  • The best practices of successful clinical research programs and review common pitfalls to avoid

 

This webinar will benefit CEOs, CNOs, physician practice management leaders, IRB administrators or board members, private practice site administrators, and research site personnel.

Registration Fee: $200 per site registration (includes one phone connection and one internet connection for unlimited participants in the same location)

To learn more, click here.

 

About Pearl IRB

Pearl IRB is an independent Institutional Review Board that provides comprehensive IRB services for sponsors, institutions, principal investigators, and CRO’s nationwide.We deliver quality and timely reviews that balance the interests of human subjects, sponsors, and institutions. Together, we will drive enhanced efficiency and value in clinical research.To learn more, please visit us atwww.pearlirb.com, call us at 317.278.4100, or emailinfo@pearlirb.com.

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WEBINAR

 

Integrating and Sustaining Clinical Research

 

June 9, 2011

3:00- 4:30 P.M. EST

Register Now

Featured Speakers Gretchen Bowker-the chief operating officer for Pearl IRB. She has over 25 years experience in the development of pharmaceuticals, biologics, and devices and is a recognized expert in regulatory issues, bioethics, and compliance. Gretchen has over 15 years experience at both Eli Lilly and Roche Diagnostics.

Kara Mezgerthe associate director of clinical affairs at Zimmer and a seasoned device development leader. At Zimmer, Kara has led a team of clinical researchers that supports all clinical research activities and regulatory support documents for 510k class I-II and PMA devices.

Robert Plant – the director of the Parkview Hospital Research Center in Ft. Wayne. He serves Parkview Community Hospital, primary investigators, and sponsors by conducting high quality research programs. Robert has worked with large sponsors such as St. Jude Medical, Sanofi-Aventis, Merck, Genentech, Astra Zeneca, and Medtronic to deliver high quality clinical trials which have resulted in dozens of new innovations being launched into the marketplace.

 

Need assistance with an IRB review or clinical trials?

Contact Us 

Check out our Website and Blog atwww.pearlirb.com

 

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Honey Reduces Antibiotic Resistance

I visited a local Honey Farm with my son’s preschool class earlier this year.  The owner was extolling the virtues of honey, talking about how honey had great antibacterial properties, was great for coughs, and, my personal favorite, how honey never spoiled. He actually said that honey found in the Pharos’s tombs from thousands of years ago could still be eaten today, so good were the antimicrobial properties.  At the time, I attributed this to someone who was a bit overly zealous about his product.  It turns out honey can reduce antibiotic resistance and clear chronically infected wounds, according to research presented at the Society for General Microbiology’s Spring Conference in Harrogate.

“Manuka honey could be an efficient way to clear chronically infected wounds and could even help reverse bacterial resistance to antibiotics, according to research presented at the Society for General Microbiology’s Spring Conference in Harrogate.

“Our findings with streptococci and pseudomonads suggest that manuka honey can hamper the attachment of bacteria to tissues which is an essential step in the initiation of acute infections. Inhibiting attachment also blocks the formation of biofilms, which can protect bacteria from antibiotics and allow them to cause persistent infections,” explained Professor Cooper. “Other work in our lab has shown that honey can make MRSA more sensitive to antibiotics such as oxacillin – effectively reversing antibiotic resistance. This indicates that existing antibiotics may be more effective against drug-resistant infections if used in combination with manuka honey.””

I’m sorry I doubted you, honey man… Perhaps tomorrow morning I will dust off the bottle of honey that has been biding its time in the back of my pantry for the last 10 years, pop it in the microwave to dissolve the crystals as per your instructions,  and use it on my breakfast toast.

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Rubber Skin- Could Plastic Man Become a Reality?

File this under the “this is totally cool” category:

Zhenan Bao, head researcher of the project and associate professor of chemical engineering at Stanford, created a sheet of rubber-based skin that could detect the slightest changes in pressure, so sensitive that it could feel a fly touch down. More recently, Bao has succeeded in adding chemical and biological sensors and has shown that it can detect a certain kind of DNA. Most recently, her team has developed a new, stretchable solar cell that can power this super skin.

See more in Medgadget

This takes me back to the Plastic Man cartoons I used to watch when I was a kid. Perhaps “He can spring! He can stretch! He can fly! He can bounce! He can change his shape!” sounds a bit far-fetched, but who knows what the future will bring?

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November 6, 2010 – Pearl IRB Speaking at the ACRP Excellence in Clinical Research Fall Symposium

Pearl IRB is speaking on a panel and exhibiting at the ACRP Excellence in Clinical Research Fall Symposium – REGISTER NOW!
Don’t miss the Circle City ACRP Event
held on November 6, 2010

Who should attend:

All personnel who are involved in or planning to be involved in clinical research. This conference is targeted for both new and experienced clinical research professionals including research nurses, clinical research coordinators, investigators, site managers, IRB members, and Pharmaceutical & Medical Device representatives.

What will be covered:

The pursuit of excellence in clinical research will be presented from the perspective of each of the major clinical research stakeholders. Click here for full agenda and brochure.

Date:   November 6, 2010

Time:  7:30am – 4:30pm

Where:  Indianapolis, Indiana at the downtown University Place Hotel

Register now!

This Event Has Been Approved for 7.5 Contact Hours

About Pearl IRB

Pearl IRB is an independent Institutional Review Board that provides comprehensive IRB services for institutions, principal investigators, and CRO’s nationwide.We deliver quality and timely reviews that balance the interests of human subjects, sponsors, and institutions. Together, we will drive enhanced efficiency and value in clinical research.To learn more, please visit us at www.pearlirb.com, call us at 317.278.4100, or email info@pearlirb.com.

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Eli Lilly Rolls Out Diagnostics Division

…”Diagnostics division to help drugmaker tailor treatments.”

Eli Lilly has created a new division to produce tests that will “winnow out the patients most likely to benefit from a Lilly drug.” This new concept of “personalized medicine” recognizes the reality that most drugs work in only about 1/3 of the patients who take them. These new tests will help Lilly identify the subgroups of patients who will benefit the most and at what dose. The diseases that this new Lilly division will be focusing on are Cancer and Alzheimer’s.

Will there be a trend for the life sciences industry that will push pharma companies to develop diagnostic tests alongside their experimental drugs? Terry Hisey, leader of the US life sciences practice, Deloitte Consulting, believes there will be.

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May 24, 2010 – FDA Issues: Making Good Drug and Device Investment Decisions

FDA Issues: Making Good Drug and Device Investment Decisions

Topics will include:

  • FDA & Regulatory Developments
  • Washington Update
  • Keeping Your Strategy Together & On Schedule
  • Finances: Successful Entry & Exit

Monday, May 24, 2010
Breakfast beginning at 7:00 a.m. EDT
Program from 7:30 a.m. – 9:00 a.m. EDT

Indiana University Emerging Technologies Center (IUETC)
351 West Tenth Street
Indianapolis, Indiana

RSVP by May 17, 2010 to Jana Langebartels at jana.langebartels@bakerd.com or 317-569-4614.

This program is presented free of charge, however you must RSVP in order to attend.

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June 16, 2010 – St. Vincent Health’s 6th Annual Research Symposium

St. Vincent Health’s 6th Annual Research Symposium is scheduled for June 16, 2010 in Indianapolis.  As part of the Symposium we will hold our annual research abstract presentation and competition. Please plan to attend the Symposium.  Save the date and look for further details and registration information in the coming weeks.

View 2009′s Symposium Presentations

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The Importance of Doing Your Homework

We frequently discuss the importance of planning and doing research before jumping in and committing dollars to building a device or even creating a conceptual design. However, from time to time, we are hired to help individuals or companies get their devices to market after they have a design or product created. It’s a simple concept…

IDEA –> STRATEGY & FEASIBILITY –> FDA PATH –> PRODUCT DESIGN –> FINAL PRODUCT

The most successful ideas happen when the inventor/entrepreneur comes to us BEFORE the design phase and those companies that focus on the designing of products advise their clients to approach a company like Creo Quality BEFORE the design phase.

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